解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
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免疫学
传染病
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基本医疗保健
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热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The use of steroid hormones as growth promoters remains illegal in Europe. A classical approach used to control their utilization consists to measure the parent drug in target biological matrices. However, this strategy may fail when the parent drug is submitted to extensive metabolism reactions. For urine and tissue ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.11.009
更新日期:2005-03-01 00:00:00
abstract::Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.11.001
更新日期:2005-03-01 00:00:00
abstract::16alpha-hydroxydehydroepiandrosterone was for the first time detected in human seminal plasma by using a combination of extraction, solvent partition, HPLC separation and final quantification by GC-MS as pentafluorobenzyloxime trimethylsilyl ether derivative in SIM mode. Three effective mass fragments m/z 266, 356 and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.05.017
更新日期:2004-10-01 00:00:00
abstract::Five new steroidal alkaloids, 5,14-dehydro-N(a)-demethylsaracodine [3beta-N(a)-methyl-20S-N(b)-acetyl-N(b)-methylamino-pregn-5,14-diene] (1), 14-dehydro-N(a)-demethylsaracodine [3beta-N(a)-methyl-20S-N(b)-acetyl-N(b)-methylamino-5alpha-pregn-14-ene] (2), 16-dehydrosarcorine [(20S)-20-(N,N-dimethylamino)-3beta-(N(a)-ac...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.03.016
更新日期:2004-10-01 00:00:00
abstract::Estrogen results in the suppression of experimental allergic encephalomyelitis (EAE), a frequently used experimental animal model of multiple sclerosis (MS). The mechanism by which estrogen acts in diseases with an autoimmune background is less clear. Here, we used splenic dendritic cells (DC) from the Lewis rats EAE ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.05.019
更新日期:2004-09-01 00:00:00
abstract::Osteoblasts are a main target for the steroid 1alpha,25(OH)2-Vitamin D3 (1,25D3), where a major outcome is the modulation of the bone remodeling process. 1,25D3 deficiency leads to clinical disorders such as osteomalacia and osteoporosis, characterized by a state of insufficiently calcified tissue and bone loss, respe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.05.003
更新日期:2004-08-01 00:00:00
abstract::A number of testosterone analogs with a 13,14-secosteroidal fragment have been prepared from (13S)-13-iodo-6beta-methoxy-3alpha, 5-cyclo-13,14-seco-5alpha-androstan-14,17-dione. The key steps involved stereoselective deiodination of the starting compound with triphenylphosphine and selective protection of the 17-keto ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.04.010
更新日期:2004-07-01 00:00:00
abstract::A variety of compounds, including the selective estrogen receptor (ER) modulators tamoxifen and raloxifene, phytoestrogens such as genistein, and xenoestrogens such as bisphenol, bind to the estrogen receptor and elicit biological responses. Structural studies have linked the altered activity of compounds such as 4-hy...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2004.03.014
更新日期:2004-06-01 00:00:00
abstract::Five new C21 steroidal glycosides, namely, komarosides D (1), E (2), F (3), G (4), and H (5), along with two known C21 steroidal glycosides cynatratoside E (6) and hancoside A (7), were isolated from the ethanol extract of the roots of Cynanchum komarovii Al. Iljinski (Asclepiadaceae). Their structures were determined...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.03.001
更新日期:2004-05-01 00:00:00
abstract::Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.01.003
更新日期:2004-04-01 00:00:00
abstract::Estradiol (E2) and other steroids have recently been shown to initiate various intracellular signaling cascades from the plasma membrane, including those stimulating mitogen-activated protein kinases (MAPKs), and particularly extracellular-regulated kinases (ERKs). In this study we demonstrated the ability of E2 to ac...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.12.003
更新日期:2004-03-01 00:00:00
abstract::Plasma concentrations of dehydroepiandrosterone (DHEA), 5-androstene-3beta,17beta-diol (AED), and 17beta-estradiol (E2) in dairy cows and heifers and AED binding to uterine cytosolic estrogen receptor (ER) were studied. Plasma samples were collected from the subcutaneous abdominal (SA) and jugular (J) veins of heifers...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.12.001
更新日期:2004-02-01 00:00:00
abstract::In this study, we investigated the binding characteristics of [3H]Delta(5)-androstene-3beta,17beta-diol to rabbit vaginal cytosolic and nuclear extracts and in freshly excised intact tissue strips. [3H]delta(5)-Androstene-3beta,17beta-diol bound to a protein(s) in the vaginal nuclear extract with high affinity (K(d)=3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.10.006
更新日期:2004-01-01 00:00:00
abstract::Two isoforms of the androgen receptor (AR-A and AR-B), differing by a lack of the first 187 amino acids in the NH2-terminal transactivation domain of AR-A, are expressed in connective tissue and bone. Transient transfections of normal human osteoblastic cells (HOB) and of genital skin fibroblasts defective in AR (GSF-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.08.016
更新日期:2003-12-01 00:00:00
abstract::At the development of receptivity the endometrium undergoes specific changes. Several factors have been suggested as markers of endometrial receptivity. A common feature for most of these factors is that they are directly, or indirectly, regulated by progesterone. The effect of various doses and regimens of mifepristo...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(03)00131-4
更新日期:2003-11-01 00:00:00
abstract::A variety of progestins are available for therapeutic use. It is convenient to classify them into those related in chemical structure to progesterone or testosterone. Progestins related to progesterone can be subdivided into pregnanes and 19-norpregnanes, whereas those related to testosterone can be subdivided into th...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2003.08.003
更新日期:2003-11-01 00:00:00
abstract::Progestagens inhibit growth of endometrial cancer cells in vivo and in vitro, and also are reported to inhibit endometrial cancer cell invasion. The progesterone receptor (PR) isotypes PRA and PRB have different transcriptional activity. There are indications that relative over expression of PRB could lead to developm...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.08.002
更新日期:2003-11-01 00:00:00
abstract::Estradiol (E2), progesterone (P4), and oxytocin (OT) are important for the initiation of luteolysis in ruminants but the mechanisms involved are still poorly understood. The objective of this study was to determine if duration of exposure of bovine endometrial epithelial cells to P4 affected the response of the cells ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(03)00094-1
更新日期:2003-09-01 00:00:00
abstract::Adrenal function and aging have been the object of intense interest in recent years. In this study we analyzed morning (08:00 h) serum cortisol concentrations from a sample of Chinese subjects aged from 31 to 110 years. These levels differed according to age, health status and sex, although the sex difference was conf...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(03)00083-7
更新日期:2003-08-01 00:00:00
abstract::During the periparturient period, dairy cows are subjected to physiological changes that may induce immunosuppression and an increased susceptibility of the animal to bacterial infections such as mastitis. The incidence of clinical environmental mastitis is high during the last period of gestation, at parturition and ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(03)00040-0
更新日期:2003-05-01 00:00:00
abstract::A novel steroid, 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one (gibberoketosterol) (1), along with four known steroids, was isolated from the lipophilic extracts of a Taiwanese soft coral Sinularia gibberosa. The structure of the new metabolite was determined on the basis of extensive spectral analyses and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(03)00036-9
更新日期:2003-04-01 00:00:00
abstract::The conversion of testosterone (T) to 5alpha-dihydrotestosterone (DHT) has been demonstrated in Penicillium crustosum broth obtained from fermented pistachios, lemons and corn tortillas. Furthermore, the presence of 5alpha-reductase enzyme, which is responsible for this conversion, has been established by electrophore...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00180-0
更新日期:2003-03-01 00:00:00
abstract::(20S)-[7,7,21,21-2H(4)]-3beta-(tert-Butyldimethylsilanyloxy)-20-methyl-pregn-5-en-21-ol, an intermediate for the preparation of deuterated isotopomers of sterols to be used as standards for biomedical studies, was prepared by reduction with dichloroaluminum deuteride of ethyl (20S)-3beta-(tert-butyldimethylsilanyloxy)...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00172-1
更新日期:2003-02-01 00:00:00
abstract::The receptor profiles and in vivo activity of tibolone, and its primary metabolites, Delta(4)-isomer, and 3alpha- and 3beta-hydroxytibolone, were studied and compared to those of structurally related compounds. The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00112-5
更新日期:2003-01-01 00:00:00
abstract::We describe the development of a serum chlormadinone acetate (CMA) time-resolved fluoroimmunoassay (TR-FIA). We prepared haptens (3-CMO-chlormadinone acetate and 6-chloropregna-4,6-dien-17,20-diol-3-one-20-hemisuccinate), biotinylated tracers (3(biotinylaminopropylamido) 3-CMO-chlormadinone acetate and 3-(6-chloropreg...
journal_title:Steroids
pub_type: 临床试验,杂志文章
doi:10.1016/s0039-128x(02)00050-8
更新日期:2002-12-01 00:00:00
abstract::Some intermediates in the cholesterol biosynthesis between lanosterol and cholesterol are capable of inducing resumption of meiosis in cultured mouse oocytes without the presence of gonadotropins. The mechanism by which these so-called Meiosis Activating Sterols (MAS) activate the meiotic process is unknown, and it is...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00041-7
更新日期:2002-11-01 00:00:00
abstract::A first assay based on stable isotope dilution/gas chromatography-mass spectrometry (ID/GC-MS) has been developed for plasma 11-deoxycortisol (Reichstein's compound S), the leading hormonal marker of 11beta-hydroxylase deficiency. A suitable internal standard being unavailable, we synthesized dideuterated 11-deoxycort...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00052-1
更新日期:2002-09-01 00:00:00
abstract::Plasma concentration measurements of 13C-labeled cortisol ([1,2,4,19-13C(4)]cortisol, cortisol-13C(4)) and its metabolite cortisone-13C(4) were made simultaneously with measurements of endogenous cortisol and cortisone by gas chromatography-mass spectrometry (GC-MS). After administering a small amount (3mg) of cortiso...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00037-5
更新日期:2002-08-01 00:00:00
abstract::Gonadal steroids modulate adrenal gland size and function in a variety of species, and our previous studies demonstrate that circulating androgens suppress 3beta-hydroxysteroid dehydrogenase-isomerase (3betaHSD) activity in the adrenal cortex of male mice. The present study tests the hypothesis that androgens have a d...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00023-5
更新日期:2002-07-01 00:00:00
abstract::This article describes the oxidation of cholesta-5,7-dien-3beta-yl acetate (4) with the urea-hydrogen peroxide adduct (UHP) using methyltrioxorhenium (MTO) as catalyst, under various conditions. Specifically, the effects of using different solvents (CHCl(3) and ethers) and additives (EtOH and pyridine) on the course o...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00017-x
更新日期:2002-06-01 00:00:00
abstract::Homogeneous catalytic hydrazinocarbonylation of some steroid derivatives possessing iodo-alkenyl moiety (17-iodo-androst-16-ene 1, 17-iodo-3-methoxy-estra-1,3,5(10),16-tetraene 2, 17-iodo-4-aza-4-methyl-androst-16-en-3-one 3 and 17-iodo-6beta-hydroxy-3alpha,5alpha-cycloandrost-16-ene 4) were carried out in the presenc...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00006-5
更新日期:2002-06-01 00:00:00
abstract::Early work in the field established that the 5 alpha-reduced metabolite of progesterone 3 alpha-OH-5 alpha-pregnan-20-one (allopregnanolone or 3 alpha,5 alpha-THP) is a potent positive modulator of the GABA(A) receptor (GABAR), the receptor mediating the effects of the primary inhibitory transmitter in the brain. This...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00170-2
更新日期:2002-05-01 00:00:00
abstract::Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation by estrogen of the coupling of various receptor systems to inwardly rectifying and small conductance, Ca(2+)-activated K(+) (SK) channels. We us...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(01)00181-7
更新日期:2002-05-01 00:00:00
abstract::Four new pregnane glycosides, stelmatocryptonoside A, B, C, and D (1-4), were isolated from the stems of Stelmatocrypton khasianum. On the basis of chemical and spectral data, the structures of 1-4 were established as 3beta, 16alpha-dihydroxy-pregn-5-en-20-one-16-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00187-8
更新日期:2002-04-01 00:00:00
abstract::Steroidal nucleoside analogs were synthesized starting from testosterone. By reduction of the oxime of 17 beta-hydroxy-androst-4-en-3-one (testosterone), a mixture of the two amino epimers of C-3 were obtained. The 3 alpha-amino-androst-4-en-17 beta-ol was crystallized in 73% yield and coupled with 5-amino-4,6-dichlor...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00157-x
更新日期:2002-03-01 00:00:00
abstract::Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. Al...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00149-0
更新日期:2002-03-01 00:00:00
abstract::Orally administered testosterone undecanoate (TU), an anabolic, androgenic steroid, can potentially be abused by athletes. Indirect evidence for detecting oral TU intake could be deduced from the changes in steroid profile post-administration. Direct evidence could be obtained by detection of unchanged TU in plasma. T...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00128-3
更新日期:2002-01-01 00:00:00
abstract::Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00112-x
更新日期:2001-11-01 00:00:00
abstract::From the fruiting bodies of Ascomycetes Tuber indicum, a new steroidal glucoside with polyhydroxy ergosterol nucleus, tuberoside (2), has been isolated along with additional four known ergosterol derivatives, (22E, 24R)-ergosta-7, 22-dien-3beta, 5alpha, 6beta-triol (1), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6, 22...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00105-2
更新日期:2001-10-01 00:00:00
abstract::Two new polyhydroxysteroids isihippurols A (1) and B (2) were isolated from the MeOH extract of the gorgonian Isis hippuris in addition to nine known steroids namely gorgosterol, 3alpha-acetoxy-24-methyl 11beta,18; 18,20beta; 22,25-triepoxy-5alpha-furostane, hippurin-1, 22-epi-hippuristanol, 22-epi-hippurin-1, 3-acety...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00098-8
更新日期:2001-09-01 00:00:00